The peptide interacts with two types of opioid receptors: µ and δ. ΒEndorphin is a neuropeptide consisting of 31 amino acids and formed in the hypophysis as a result of cleavage of proopiomelanocortin (POMC).
DOI: 10.1134/S0006297911040018 Key words: βendorphin peptides, naloxoneinsensitive receptor, immune system, nervous system, adrenal glands The discussed information is supposed to extend our conceptions of the role of βendorphin in mammals and to be of extensive use in medicine and pharmacology. All available data on the characteristics of the nonopioid βendorphin receptor obtained by means of radioligand analysis are given. The data on distribution and function of the nonopioid βendorphin receptor in human and animal organisms are presented. The effect of neuromediator on the immune system mediated by both opioid and nonopi oid receptors is considered in detail. The roles of the hormone and its receptors in regulation of the immune, nervous, and endocrine systems are discussed. Nauki 6, 142290 Pushchino, Moscow Region, Russia fax: (4967) 330527 Email: Received JRevision received AugAbstract-This review presents the generalized literature data and the results of our own research of the nonopioid effect of βendorphin, an opioid neuropeptide interacting not only with opioid but also with nonopioid (insensitive to the opioid antagonist naloxone) receptors. Navolotskaya Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, pr. Published in Russian in Biokhimiya, 2011, Vol.
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